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Article

PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper.

The American journal of pathology - 1 Apr 2002

Kim Kyoung-Mee, Salovaara Reijo, Mecklin Jukka-Pekka, Järvinen Heikki J, Aaltonen Lauri A, Shibata Darryl

Abstract excerpt

Microsatellite instability (MSI) secondary to loss of DNA mismatch repair (MMR) is present in adenomas and colorectal carcinomas from individuals with hereditary nonpolyposis colorectal cancer (HNPCC). To better characterize when MMR loss occurs during HNPCC progression, the extent of deletions in noncoding polyA sequences were compared between 6 adenomas (all < or = 1.0 cm in size) and 10 cancers. Numbers of...

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Source

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Identifiers

PMID: 11943734
DOI: 10.1016/S0002-9440(10)62576-X
PMCID: PMC1867223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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