Article
Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2014
Pedraza Otto, Allen Mariet, Jennette Kyle, Carrasquillo Minerva, Crook Julia, Serie Daniel, Pankratz V Shane, Palusak Ryan, Nguyen Thuy, Malphrus Kimberly, Ma Li, Bisceglio Gina, Roberts Rosebud O, Lucas John A, Ivnik Robert J, Smith Glenn E, Graff-Radford Neill R, Petersen Ronald C, Younkin Steven G, Ertekin-Taner Nilüfer
Abstract excerpt
BACKGROUND: Genetic variants at the CLU, CR1, and PICALM loci associate with risk for late-onset Alzheimer's disease (LOAD) in genomewide association studies. In this study, our aim was to determine whether the LOAD risk variants at these three loci influence memory endophenotypes in black and white subjects. METHODS: We pursued an association study between single nucleotide polymorphism genotypes at the CLU,...
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