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Article

Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice.

PloS one - 1 Jan 2012

Sheng Matilda H-C, Wergedal Jon E, Mohan Subburaman, Amoui Mehran, Baylink David J, Lau K-H William

Abstract excerpt

This study sought to test whether targeted overexpression of osteoactivin (OA) in cells of osteoclastic lineage, using the tartrate-resistant acid phosphase (TRAP) exon 1B/C promoter to drive OA expression, would increase bone resorption and bone loss in vivo. OA transgenic osteoclasts showed ∼2-fold increases in OA mRNA and proteins compared wild-type (WT) osteoclasts. However, the OA expression in transgenic...

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Identifiers

PMID: 22536365
DOI: 10.1371/journal.pone.0035280
PMCID: PMC3335057

Genes

ADAM12
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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