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Article

The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function.

Bone - 1 May 2001

Rajapurohitam V, Chalhoub N, Benachenhou N, Neff L, Baron R, Vacher J

Abstract excerpt

The osteopetrotic grey-lethal (gl) mouse mutant displays many similarities to the human malignant autosomal-recessive form of osteopetrosis. In this study, we show that the gl osteopetrotic bone phenotype is characterized by the presence of numerous differentiated multinucleated osteoclasts. A significant increase in the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts was detected in...

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PMID: 11344051
DOI: 10.1016/s8756-3282(01)00416-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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