Article
Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro.
The American journal of pathology - 1 Mar 2014
Abdelmagid Samir M, Belcher Joyce Y, Moussa Fouad M, Lababidi Suzanne L, Sondag Gregory R, Novak Kimberly M, Sanyurah Afif S, Frara Nagat A, Razmpour Roshanak, Del Carpio-Cano Fabiola E, Safadi Fayez F
Abstract excerpt
We have previously identified osteoactivin (OA), encoded by Gpnmb, as an osteogenic factor that stimulates osteoblast differentiation in vitro. To elucidate the importance of OA in osteogenesis, we characterized the skeletal phenotype of a mouse model, DBA/2J (D2J) with a loss-of-function mutation in Gpnmb. Microtomography of D2J mice showed decreased trabecular mass, compared to that in wild-type mice...
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