Article
Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1) receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice.
Arthritis and rheumatism - 1 Feb 2010
Kara Firas M, Doty Stephen B, Boskey Adele, Goldring Steven, Zaidi Mone, Fredholm Bertil B, Cronstein Bruce N
Abstract excerpt
OBJECTIVE: Accelerated osteoclastic bone resorption plays a central role in the pathogenesis of osteoporosis and other bone diseases. Because identifying the molecular pathways that regulate osteoclast activity provides a key to understanding the causes of these diseases and developing new treatm...
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