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Article

Transgenic mice that express Cre recombinase in osteoclasts

1 Jul 2004

Abstract excerpt

To study the physiological control of osteoclasts, the bone resorbing cells, we generated transgenic mice carrying the Cre recombinase gene driven by either the tartrate-resistant acid phosphatase (TRAP) or cathepsin K (Ctsk) promoters. TRAP-Cre and Ctsk-Cre transgenic mouse lines were characterized by breeding with LacZ ROSA 26 (R26R) reporter mice and immunohistochemistry for Cre recombinase. The Cre transgene...

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PMID: 15282744
DOI: 10.1002/gene.20041

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