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Article

Osteoblast-targeted overexpression of TAZ increases bone mass in vivo.

PloS one - 1 Jan 2013

Yang Jae-Yeon, Cho Sun Wook, An Jee Hyun, Jung Ju Yeon, Kim Sang Wan, Kim Seong Yeon, Kim Jung Eun, Shin Chan Soo

Abstract excerpt

Osteoblasts are derived from mesenchymal progenitors. Differentiation to osteoblasts and adipocytes is reciprocally regulated. Transcriptional coactivator with a PDZ-binding motif (TAZ) is a transcriptional coactivator that induces differentiation of mesenchymal cells into osteoblasts while blocking differentiation into adipocytes. To investigate the role of TAZ on bone metabolism in vivo, we generated transgenic...

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Identifiers

PMID: 23441207
DOI: 10.1371/journal.pone.0056585
PMCID: PMC3575506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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