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Article

High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage.

Molecular and cellular biology - 1 Sept 2002

Geoffroy Valérie, Kneissel Michaela, Fournier Brigitte, Boyde Alan, Matthias Patrick

Abstract excerpt

The runt family transcription factor core-binding factor alpha1 (Cbfa1) is essential for bone formation during development. Surprisingly, transgenic mice overexpressing Cbfa1 under the control of the 2.3-kb collagen type I promoter developed severe osteopenia that increased progressively with age and presented multiple fractures. Analysis of skeletally mature transgenic mice showed that osteoblast maturation was...

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Identifiers

PMID: 12167715
DOI: 10.1128/MCB.22.17.6222-6233.2002
PMCID: PMC134019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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