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Article

Generation of Mouse Osteoclastogenic Cell Lines Immortalized with SV40 Large T Antigen

1 Jul 1998

Abstract excerpt

Progress in the field of osteoclast gene regulation has been hampered significantly by the lack of such cell lines. In this study, mouse osteoclast precursor cells were elicited in an osteoclast-inductive coculture system and immortalized using SV40 large T antigen. One of the osteoclast precursor cell lines (MOCP-5) forms 95% tartrate-resistant acid phosphatase positive (TRAP+) multinuclear osteoclast-like cells...

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PMID: 9661075
DOI: 10.1359/jbmr.1998.13.7.1112

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