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Article

Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.

The Journal of biological chemistry - 14 Aug 2015

Abdelmagid Samir M, Sondag Gregory R, Moussa Fouad M, Belcher Joyce Y, Yu Bing, Stinnett Hilary, Novak Kimberly, Mbimba Thomas, Khol Matthew, Hankenson Kurt D, Malcuit Christopher, Safadi Fayez F

Abstract excerpt

We previously reported on the importance of osteoactivin (OA/Gpnmb) in osteogenesis. In this study, we examined the role of OA in osteoclastogenesis, using mice with a nonsense mutation in the Gpnmb gene (D2J) and wild-type controls (D2J/Gpnmb(+)). In these D2J mice, micro-computed tomography and histomorphometric analyses revealed increased cortical thickness, whereas total porosity and eroded surface were...

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Identifiers

PMID: 25837253
DOI: 10.1074/jbc.M114.624270
PMCID: PMC4536424

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