Article
Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest.
Molecules and cells - 1 May 2012
Chang Ziwei, Lu Ming, Park Sung-Min, Park Hyun-Kyung, Kang Ho Sung, Pak Youngshang, Park Jang-Su
Abstract excerpt
The present study highlighted the aromatic-participant interactions in in vivo trimerization of HSF1 and got an insight into the process of HSF1 protecting against apoptosis. In mouse embryonic fibroblasts (MEFs), mutations of mouse HSF1 (W37A, Y60A and F104A) resulted in a loss of trimerization activity, impaired binding of the heat shock element (HSE) and lack of heat shock protein 70 (HSP70) expression after a...
Topics
- Amino Acids
- Animals
- Apoptosis
- Cell Cycle Checkpoints
- Cell Death
- Cells, Cultured
- DNA-Binding Proteins
- Fibroblasts
- G2 Phase Cell Cycle Checkpoints
- HSP70 Heat-Shock Proteins
- Heat Shock Transcription Factors
- Heat-Shock Response
- Mice