Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest.

Cell stress & chaperones - 1 Oct 2001

Luft J C, Benjamin I J, Mestril R, Dix D J

Abstract excerpt

Mammalian cells respond to environmental stress by activating heat shock transcription factors (eg, Hsf1) that regulate increased synthesis of heat shock proteins (Hsps). Hsps prevent the disruption of normal cellular mitosis, meiosis, or differentiation by environmental stressors. To further characterize this stress response, transformed wild-type Hsf1+/+ and mutant Hsf1-/- mouse embryonic fibroblasts (MEFs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Cell Line, Transformed
Share to G2 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heat-Shock Proteins

Share to Heat-Shock Response

Share to Heat Shock Transcription Factors

Share to Hot Temperature

Share to Mitosis

Source

Open in PubMed Open full text

Identifiers

PMID: 11795469
DOI: 10.1379/1466-1268(2001)006<0326:hsfmtp>2.0.co;2
PMCID: PMC434415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heat shock factor 1-mediated thermotolerance prevents cell death and results in G2/M cell cycle arrest.PMID 11795469Read ↗

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.Semantic proximity Read ↗

Mouse Heat-Shock Factor 1 (HSF1) Is Involved in Testicular Response to Genotoxic Stress Induced by Doxorubicin1Semantic proximity Read ↗

Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis.Semantic proximity Read ↗

Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest.Semantic proximity Read ↗

HSF1, a versatile factor in tumorogenesis.Semantic proximity Read ↗

Modulation of tolerance by mutant heat shock transcription factors.Semantic proximity Read ↗

Suppression of heat shock transcription factor HSF1 in zebrafish causes heat-induced apoptosis.Semantic proximity Read ↗

Phenotypic characterization of mouse embryonic fibroblasts lacking heat shock factor 2.Semantic proximity Read ↗

Non-oncogene addiction and the stress phenotype of cancer cells.Semantic proximity Read ↗

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse modelsSemantic proximity Read ↗

Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblastsSemantic proximity Read ↗

Stress Inducibility of SIRT1 and Its Role in Cytoprotection and CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.