Article

Intermolecular interactions between cysteine and aromatic amino acids with phenyl moiety in the DNA-binding domain of heat shock factor 1 regulate thermal stress-induced trimerization

2023-11-22

Abstract excerpt

In this study, we investigated the trimerization mechanism and structure of heat shock factor 1 (HSF1) in humans, goldfish, and walleye pollock at various temperatures. The trimerization of HSF1s were confirmed using western blotting using their respective antibodies. First, we examined the HSF1 DNA-binding domains of human (Homo sapiens), goldfish (Carassius auratus), and walleye pollock (Gadus chalcogrammus) by...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a04cfa2-43f4-5d5a-9a96-0ae86eb97e98
DOI: 10.1101/2023.11.21.568196

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intermolecular interactions between cysteine and aromatic amino acids with phenyl moiety in the DNA-binding domain of heat shock factor 1 regulate thermal stress-induced trimerizationDOI 10.1101/2023.11.21.568196Read

Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.Semantic proximity Read

Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest.Semantic proximity Read

The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its Interplay with TG2Semantic proximity Read

Determine genetic variations in heat shock factor gene family (HSFs) and study their effect on the functional and structural characterization of protein in Tali goat.Semantic proximity Read

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregationSemantic proximity Read

Human coronaviruses activate and hijack the proteostasis guardian HSF1 to enhance viral replicationSemantic proximity Read

Differential recognition of heat shock elements by members of the heat shock transcription factor family.Semantic proximity Read

Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity.Semantic proximity Read

Regulation of Drosophila heat shock factor trimerization: global sequence requirements and independence of nuclear localization.Semantic proximity Read

Structural model of dodecameric heat-shock protein Hsp21: Flexible N-terminal arms interact with client proteins while C-terminal tails maintain the dodecamer and chaperone activity.Semantic proximity Read

Microgravity and Human Body: Unraveling the Potential Role of Heat-Shock Proteins in Spaceflight and Future Space MissionsSemantic proximity Read

Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures.Semantic proximity Read