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The Multifaceted Role of HSF1 in Pathophysiology: Focus on Its Interplay with TG2

14 Jun 2021

Abstract excerpt

The cellular environment needs to be strongly regulated and the maintenance of protein homeostasis is crucial for cell function and survival. HSF1 is the main regulator of the heat shock response (HSR), the master pathway required to maintain proteostasis, as involved in the expression of the heat shock proteins (HSPs). HSF1 plays numerous physiological functions; however, the main role concerns the modulation of...

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PMID: 34198675
DOI: 10.3390/ijms22126366

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