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Article

Human coronaviruses activate and hijack the proteostasis guardian HSF1 to enhance viral replication

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Organisms respond to proteotoxic stress by activating a cellular defense mechanism, known as the heat shock response (HSR), that triggers the expression of cytoprotective heat shock proteins (HSP) to counteract the damaging effects of proteostasis disruption. The HSR is regulated by a family of transcription factors (heat shock factors, HSFs); among six human HSFs, HSF1 acts as a proteostasis gu...

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Identifiers and source

Literature Corpus work
a3f3f3fd-ca08-5e3d-8642-cf46ab1e5a18
DOI
10.1101/2022.12.22.519205
Open publication

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Human coronaviruses activate and hijack the proteostasis guardian HSF1 to enhance viral replicationDOI 10.1101/2022.12.22.519205
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