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Article

An RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogaster.

Nucleic acids research - 1 Aug 2011

Salamanca H Hans, Fuda Nicholas, Shi Hua, Lis John T

Abstract excerpt

Heat shock transcription factor (HSF1) is a conserved master regulator that orchestrates the protection of normal cells from stress. However, HSF1 also protects abnormal cells and is required for carcinogenesis. Here, we generate an highly specific RNA aptamer (iaRNA(HSF1)) that binds Drosophila HSF1 and inhibits HSF1 binding to DNA. In Drosophila animals, iaRNA(HSF1) reduces normal Hsp83 levels and promotes...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21576228
DOI: 10.1093/nar/gkr206
PMCID: PMC3159435

Genes

HSF1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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