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Article

Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.

Genes & development - 15 Feb 2003

Ahn Sang-Gun, Thiele Dennis J

Abstract excerpt

The activation of eukaryotic heat shock protein (Hsp) gene expression occurs in response to a wide variety of cellular stresses including heat shock, hydrogen peroxide, uncoupled oxidative phosphorylation, infection, and inflammation. Biochemical and genetic studies have clearly demonstrated critical roles for mammalian heat shock factor 1 (HSF1) in stress-inducible Hsp gene expression, resistance to...

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Identifiers

PMID: 12600944
DOI: 10.1101/gad.1044503
PMCID: PMC195992

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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