Article
A delayed antioxidant response in heat-stressed cells expressing a non-DNA binding HSF1 mutant.
Cell stress & chaperones - 1 Jul 2013
Hensen Sanne M M, Heldens Lonneke, van Genesen Siebe T, Pruijn Ger J M, Lubsen Nicolette H
Abstract excerpt
To assess the consequences of inactivation of heat shock factor 1 (HSF1) during aging, we analyzed the effect of HSF1 K80Q, a mutant unable to bind DNA, and of dnHSF1, a mutant lacking the activation domain, on the transcriptome of cells 6 and 24 h after heat shock. The primary response to heat shock (6 h recovery), of which 30 % was HSF1-dependent, had decayed 24 h after heat shock in control cells but was...
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