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Article

Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks.

Biological psychiatry - 1 Aug 2008

Bertolino Alessandro, Di Giorgio Annabella, Blasi Giuseppe, Sambataro Fabio, Caforio Grazia, Sinibaldi Lorenzo, Latorre Valeria, Rampino Antonio, Taurisano Paolo, Fazio Leonardo, Romano Raffaella, Douzgou Sofia, Popolizio Teresa, Kolachana Bhaskar, Nardini Marcello, Weinberger Daniel R, Dallapiccola Bruno

Abstract excerpt

BACKGROUND: Dopamine modulation of neuronal activity in prefrontal cortex maps to an inverted U-curve. Dopamine is also an important factor in regulation of hippocampal mediated memory processing. Here, we investigated the effect of genetic variation of dopamine inactivation via catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) on hippocampal activity in healthy humans during different memory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18374902
DOI: 10.1016/j.biopsych.2008.02.001

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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