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Article

Genetic polymorphisms regulating dopamine signaling in the frontal cortex interact to affect target detection under high working memory load.

Journal of cognitive neuroscience - 1 Feb 2014

Smith Christopher T, Swift-Scanlan Theresa, Boettiger Charlotte A

Abstract excerpt

Frontal-dependent task performance is typically modulated by dopamine (DA) according to an inverted-U pattern, whereby intermediate levels of DA signaling optimizes performance. Numerous studies implicate trait differences in DA signaling based on differences in the catechol-O-methyltransferase (COMT) gene in executive function task performance. However, little work has investigated genetic variations in DA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Memory, Short-Term

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Source

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Identifiers

PMID: 24144248
DOI: 10.1162/jocn_a_00501
PMCID: PMC3877727

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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