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Article

Dissection of Pol II trigger loop function and Pol II activity-dependent control of start site selection in vivo.

PLoS genetics - 1 Jan 2012

Kaplan Craig D, Jin Huiyan, Zhang Ivan Liang, Belyanin Andrey

Abstract excerpt

Structural and biochemical studies have revealed the importance of a conserved, mobile domain of RNA Polymerase II (Pol II), the Trigger Loop (TL), in substrate selection and catalysis. The relative contributions of different residues within the TL to Pol II function and how Pol II activity defects correlate with gene expression alteration in vivo are unknown. Using Saccharomyces cerevisiae Pol II as a model, we...

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Identifiers

PMID: 22511879
DOI: 10.1371/journal.pgen.1002627
PMCID: PMC3325174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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