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Article

Important role in transcription start site selection for the RNA polymerase II-TFIIE-TFIIH interface in Saccharomyces cerevisiae.

Genetics - 4 Apr 2026

Basnet Pratik, Zhu Yunye, Vvedenskaya Irina O, Arora Payal, Hammer Staci E, McVicar Brittany R, Alex Shawn Aji, Nickels Bryce E, Kaplan Craig D

Abstract excerpt

During transcription initiation in Saccharomyces cerevisiae, RNA polymerase II (Pol II) and general transcription factors (GTFs) assemble upstream of transcription start sites (TSSs) to form the preinitiation complex (PIC). In this model organism, yeast, the PIC selects TSSs through a unidirectional scanning mechanism referred to as promoter scanning. Previous studies have shown that the TFIIH subunit Tfb3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41502139
DOI: 10.1093/genetics/iyag003
PMCID: PMC12834377

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