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Article

Physiological and pathological functions of TMEM106B in neurodegenerative diseases.

Cellular and molecular life sciences : CMLS - 6 May 2024

Zhu Min, Zhang Guoxin, Meng Lanxia, Xiao Tingting, Fang Xin, Zhang Zhentao

Abstract excerpt

As an integral lysosomal transmembrane protein, transmembrane protein 106B (TMEM106B) regulates several aspects of lysosomal function and is associated with neurodegenerative diseases. The TMEM106B gene mutations lead to lysosomal dysfunction and accelerate the pathological progression of Neurodegenerative diseases. Yet, the precise mechanism of TMEM106B in Neurodegenerative diseases remains unclear. Recently,...

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Identifiers

PMID: 38710967
DOI: 10.1007/s00018-024-05241-z
PMCID: PMC11074223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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