Article
Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain.
Acta neuropathologica communications - 11 Jul 2013
Busch Johanna I, Martinez-Lage Maria, Ashbridge Emily, Grossman Murray, Van Deerlin Vivianna M, Hu Fenghua, Lee Virginia M Y, Trojanowski John Q, Chen-Plotkin Alice S
Abstract excerpt
BACKGROUND: Frontotemporal lobar degeneration (FTLD) is the second most common cause of dementia in individuals under 65 years old and manifests as alterations in behavior, personality, or language secondary to degeneration of the frontal and/or temporal lobes. FTLD-TDP, the largest neuropathological subset of FTLD, is characterized by hyperphosphorylated, ubiquitinated TAR DNA-binding protein 43 (TDP-43)...
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