Article
Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin.
Biochimica et biophysica acta - 19 Dec 2001
Yuan L W, Gambee J E
Abstract excerpt
Signal transduction through cAMP to activate gene expression via the cAMP-responsive element (CRE) is one of the most intensively studied transcription pathways. In this pathway, transcription factor CRE-binding protein (CREB) recognizes the CRE enhancer on DNA. The CREB protein is activated via phosphorylation at serine 133 by protein kinase A and then is able to recruit coactivator CREB-binding protein (CBP)...
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