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Article

Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation.

The EMBO journal - 1 Oct 2003

Shikama Noriko, Lutz Werner, Kretzschmar Ralph, Sauter Nadine, Roth Jeanne-Françoise, Marino Silvia, Wittwer Jonas, Scheidweiler Alexander, Eckner Richard

Abstract excerpt

p300 and CBP are large nuclear acetyltransferases exhibiting a complex multi-domain structure. Mouse embryos nullizygous for either p300 or Cbp die at midgestation, while heterozygotes are viable but in part display defects in neurulation or bone morphogenesis. To directly examine the contributio...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 14517255
DOI: 10.1093/emboj/cdg502
PMCID: PMC204485

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14517255-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation.PMID 14517255Read ↗

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Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.Semantic proximity Read ↗

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