Article
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells.
Blood - 1 Jun 2006
Xu Wu, Fukuyama Tomofusa, Ney Paul A, Wang Demin, Rehg Jerold, Boyd Kelli, van Deursen Jan M A, Brindle Paul K
Abstract excerpt
CREB-binding protein (CBP) and its para-log p300 are transcriptional coactivators that physically or functionally interact with over 320 mammalian and viral proteins, including 36 that are essential for B cells in mice. CBP and p300 are generally considered limiting for transcription, yet their roles in adult cell lineages are largely unknown since homozygous null mutations in either gene or compound...
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