Article
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.
Epigenetics - 1 Jan 2010
Bedford David C, Kasper Lawryn H, Fukuyama Tomofusa, Brindle Paul K
Abstract excerpt
One general principle of gene regulation is that DNA-binding transcription factors modulate transcription by recruiting cofactors that modify histones and chromatin structure. A second implicit principle is that a particular cofactor is necessary at all the target genes where the cofactor is recruited. Increasingly, these principles do not appear to be absolute, as experimentally defined relationships between...
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