Article
Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis.
Cell research - 1 Apr 2007
Karamouzis Michalis V, Konstantinopoulos Panagiotis A, Papavassiliou Athanasios G
Abstract excerpt
CREB-binding protein (CBP) and its homologue p300 are transcriptional co-activators of various sequence-specific transcription factors that are involved in a wide array of cellular activities, such as DNA repair, cell growth, differentiation and apoptosis. Several studies have suggested that CBP and p300 might be considered as tumour suppressors, with their prominent role being the cross-coupling of distinct gene...
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