Article
Production of a mouse line with a conditional Crim1 mutant allele.
Genesis (New York, N.Y. : 2000) - 1 Sept 2012
Chiu Han Sheng, York J Philippe, Wilkinson Lorine, Zhang Pumin, Little Melissa H, Pennisi David J
Abstract excerpt
Crim1 is a developmentally expressed, transmembrane protein essential for normal embryonic development. We generated mice engineered to contain a Crim1 conditional null allele by flanking exons three and four of Crim1 with unidirectional LoxP sites. After crossing Crim1+/FLOX mice with a CMV-Cre line, a Crim1+/Δflox colony was established after germline transmission of the deleted allele. We then analyzed genomic...
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