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Article

Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2007

Pennisi David J, Wilkinson Lorine, Kolle Gabriel, Sohaskey Michael L, Gillinder Kevin, Piper Michael J, McAvoy John W, Lovicu Frank J, Little Melissa H

Abstract excerpt

Crim1 is a transmembrane protein, containing six vWF-C type cysteine-rich repeats, that tethers growth factors to the cell surface. A mouse line, KST264, generated in a LacZ insertion mutagenesis gene-trap screen, was examined to elucidate Crim1 function in development. We showed that Crim1(KST264/KST264) mice were not null for Crim1 due to the production of a shortened protein isoform. These mice are likely to...

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PMID: 17106887
DOI: 10.1002/dvdy.21015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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