Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins.

The Journal of pathology - 1 Apr 2013

Phua Yu Leng, Martel Nick, Pennisi David J, Little Melissa H, Wilkinson Lorine

Abstract excerpt

Crim1 is a transmembrane protein that regulates the bioavailability of growth factors such as VEGFA. Crim1(KST264)(/)(KST264) hypomorphic mice develop renal disease characterized by glomerular cysts and loss of endothelial integrity, progressing to peritubular and pericystic fibrosis. Peritubular capillary endothelial cells display morphological changes as well as detachment from the basement membrane. In this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epithelial-Mesenchymal Transition
Share to Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrases

Share to Kidney Diseases

Share to Luminescent Proteins

Share to Myofibroblasts

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Receptor, TIE-2

Source

Identifiers

PMID: 23224993
DOI: 10.1002/path.4155

Genes

TNF
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins.PMID 23224993Read ↗

Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.Semantic proximity Read ↗

Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice.Semantic proximity Read ↗

Production of a mouse line with a conditional Crim1 mutant allele.Semantic proximity Read ↗

Endothelial marker-expressing stromal cells are critical for kidney formation.Semantic proximity Read ↗

Pathogenic pathways are activated in each major cell type of the glomerulus in the Cd2ap mutant mouse model of focal segmental glomerulosclerosis.Semantic proximity Read ↗

Exploration of the single-cell transcriptomic landscape identifies aberrant glomerular cell crosstalk in a murine model of WT1 kidney diseaseSemantic proximity Read ↗

TNFα and Endothelial IL-1 Receptor Signaling Drive Peritubular Capillary Regression and Fibrosis in Obstructive Kidney InjurySemantic proximity Read ↗

Renal interstitial fibrosis: mechanisms and evaluation.Semantic proximity Read ↗

Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation.Semantic proximity Read ↗

Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survivalSemantic proximity Read ↗

Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome.Semantic proximity Read ↗

Emilin1 links TGF-beta maturation to blood pressure homeostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.