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Article

Integrative Bioinformatics Analysis of mRNA Expression Profiles of Mice to Explore the Key Genes Involved in Crim1 Mutation-Induced Congenital Cataracts.

Biochemical genetics - 1 Aug 2023

Zhang Ziran, Meng Fanke, Zhou Jing, Zhang Zhihan, Liang Xiaotian, Meng Meijun, Yi Guoguo, Fu Min

Abstract excerpt

Crim1 has been implicated in cataracts in mice and is of great importance in the development of the eye in both humans and mice. Therefore, we aimed to clarify how Crim1 mutations affect lens development and the molecular mechanism of cataracts in mice through comprehensive bioinformatics analysis. The microarray chip was downloaded from the GEO database to obtain the gene expression profile data set....

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Identifiers

PMID: 36586009
DOI: 10.1007/s10528-022-10323-3
PMCID: PMC10372119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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