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Article

Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.

Development (Cambridge, England) - 1 Jan 2014

Fan Jieqing, Ponferrada Virgilio G, Sato Tomohito, Vemaraju Shruti, Fruttiger Marcus, Gerhardt Holger, Ferrara Napoleone, Lang Richard A

Abstract excerpt

Angiogenesis defines the process in which new vessels grow from existing vessels. Using the mouse retina as a model system, we show that cysteine-rich motor neuron 1 (Crim1), a type I transmembrane protein, is highly expressed in angiogenic endothelial cells. Conditional deletion of the Crim1 gen...

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Topics

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Share to Autocrine Communication
Share to Endothelial Cells
Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Physiologic

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Share to Retinal Vessels

Share to Vascular Endothelial Growth Factor A

Share to Vascular Endothelial Growth Factor Receptor-2

Source

Open in PubMed Open full text

Identifiers

PMID: 24353059
DOI: 10.1242/dev.097949
PMCID: PMC3879820

Genes

CRIM1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24353059-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.PMID 24353059Read ↗

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