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Article

Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling.

Development (Cambridge, England) - 1 Jan 2014

Fan Jieqing, Ponferrada Virgilio G, Sato Tomohito, Vemaraju Shruti, Fruttiger Marcus, Gerhardt Holger, Ferrara Napoleone, Lang Richard A

Abstract excerpt

Angiogenesis defines the process in which new vessels grow from existing vessels. Using the mouse retina as a model system, we show that cysteine-rich motor neuron 1 (Crim1), a type I transmembrane protein, is highly expressed in angiogenic endothelial cells. Conditional deletion of the Crim1 gene in vascular endothelial cells (VECs) causes delayed vessel expansion and reduced vessel density. Based on known Vegfa...

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Topics

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Human Umbilical Vein Endothelial Cells

Share to Neovascularization, Physiologic

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Source

Open in PubMed Open full text

Identifiers

PMID: 24353059
DOI: 10.1242/dev.097949
PMCID: PMC3879820

Genes

CRIM1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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