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Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development.

Mechanisms of development - 1 Apr 2006

Kinna Genevieve, Kolle Gabriel, Carter Adrian, Key Brian, Lieschke Graham J, Perkins Andrew, Little Melissa H

Abstract excerpt

The Crim1 gene encodes a transmembrane protein containing six cysteine-rich repeats similar to those found in the BMP antagonist, chordin (chd). To investigate its physiological role, zebrafish crim1 was cloned and shown to be both maternally and zygotically expressed during zebrafish development in sites including the vasculature, intermediate cell mass, notochord, and otic vesicle. Bent or hooked tails with...

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Identifiers

PMID: 16524703
DOI: 10.1016/j.mod.2006.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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