Article
Crim1C140S mutant mice reveal the importance of cysteine 140 in the internal region 1 of CRIM1 for its physiological functions.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2019
Furuichi Tatsuya, Tsukamoto Manami, Saito Masaki, Sato Yuriko, Oiji Nobuyasu, Yagami Kazuhiro, Fukumura Ryutaro, Gondo Yoichi, Guo Long, Ikegawa Shiro, Yamamori Yu, Tomii Kentaro
Abstract excerpt
Cysteine-rich transmembrane bone morphogenetic protein regulator 1 (CRIM1) is a type I transmembrane protein involved in the organogenesis of many tissues via its interactions with growth factors including BMP, TGF-β, and VEGF. In this study, we used whole-exome sequencing and linkage analysis to identify a novel Crim1 mutant allele generated by ENU mutagenesis in mice. This allele is a missense mutation that...
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