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Article

A new Col1a1 conditional knock-in mouse model to study osteogenesis imperfecta.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 31 Dec 2024

Dimori Milena, Toulany Mahtab, Sultana Lira Samia, Onal Melda, Thostenson Jeff D, Carroll John L, O'Brien Charles A, Morello Roy

Abstract excerpt

Osteogenesis imperfecta (OI) constitutes a family of bone fragility disorders characterized by both genetic and clinical heterogeneity. Several different mouse models reproduce the classic features of OI, and the most commonly studied carry either a spontaneous or genetically induced pathogenic variant in the Col1a1 or Col1a2 gene. When OI is caused by primary alterations of type I collagen, it represents a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39566076
DOI: 10.1093/jbmr/zjae189
PMCID: PMC11700621

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