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Article

CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.

Journal of molecular histology - 1 Feb 2017

Iyer Swati, Chhabra Yash, Harvey Tracey J, Wang Richard, Chiu Han Sheng, Smith A G, Thomas Walter G, Pennisi David J, Piper Michael

Abstract excerpt

Endothelial cells form a critical component of the coronary vasculature, yet the factors regulating their development remain poorly defined. Here we reveal a novel role for the transmembrane protein CRIM1 in mediating cardiac endothelial cell development. In the absence of Crim1 in vivo, the coronary vasculature is malformed, the number of endothelial cells reduced, and the canonical BMP pathway dysregulated....

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Source

Identifiers

PMID: 27803996
DOI: 10.1007/s10735-016-9702-3

Genes

CRIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.PMID 27803996Read ↗

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