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Article

Frequent p53 gene mutations and novel alleles in familial breast cancer.

Cancer research - 15 Jul 1994

Glebov O K, McKenzie K E, White C A, Sukumar S

Abstract excerpt

Mutations in the p53 gene were detected in 58% of tumor DNAs of patients with a family history of breast cancer (FHBC) compared to 13% with sporadic breast cancer. Seven of 18 FHBC tumors contained the same G to C transversion in codon 156. Novel alleles of altered length were seen in one or more loci on chromosome 17 in 15 of 18 patients with FHBC but only in a single locus in 8 of 14 patients with sporadic...

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PMID: 8033087

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