Frequent p53 gene mutations and novel alleles in familial breast cancer.

Article

Frequent p53 gene mutations and novel alleles in familial breast cancer.

Cancer research - 15 Jul 1994

Glebov O K, McKenzie K E, White C A, Sukumar S

Abstract excerpt

Mutations in the p53 gene were detected in 58% of tumor DNAs of patients with a family history of breast cancer (FHBC) compared to 13% with sporadic breast cancer. Seven of 18 FHBC tumors contained the same G to C transversion in codon 156. Novel alleles of altered length were seen in one or more...

Topics

Adult
Aged
Alleles
Base Sequence
Breast Neoplasms
Chromosome Deletion
DNA Repair
Female
Genes, p53
Humans
Middle Aged
Molecular Sequence Data
Mutation

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