Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 mutations in breast cancer.

Cancer research - 1 Oct 1992

Coles C, Condie A, Chetty U, Steel C M, Evans H J, Prosser J

Abstract excerpt

We have identified and analyzed 41 mutations in p53 in sporadic breast tumors from 136 unselected breast cancer patients and estimate that approximately 40% of such tumors contain p53 mutations. The frequency of G-T transversions and the incidence of guanosine mutations in the nontranscribed stra...

Topics

Base Composition
Breast Neoplasms
Chromosomes, Human, Pair 17
Codon
Colonic Neoplasms
Female
Genes, p53
Heterozygote
Humans
Incidence
Li-Fraumeni Syndrome
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1394133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1394133-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 mutations in breast cancer.PMID 1394133Read ↗

TP53 mutation patterns in breast cancers: searching for clues of environmental carcinogenesis.Semantic proximity Read ↗

Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours.Semantic proximity Read ↗

Inherited p53 gene mutations in breast cancer.Semantic proximity Read ↗

G:C > A:T mutations and potential epigenetic regulation of p53 in breast cancer.Semantic proximity Read ↗

Rare somatic p53 mutation identified in breast cancer: a case report.Semantic proximity Read ↗

P53 gene mutations in women with breast cancer and a previous history of benign breast disease.Semantic proximity Read ↗

p53 protein accumulation and mutations in normal and benign breast tissue.Semantic proximity Read ↗

Multiple mutations of the p53 gene in human mammary carcinoma.Semantic proximity Read ↗

High frequency of G/C transversion on p53 gene alterations in breast cancers from Taiwan.Semantic proximity Read ↗

Frequency of spontaneous p53 mutations (CpG site) in breast cancer in Japan.Semantic proximity Read ↗

p73 mutations are not detected in sporadic and hereditary breast cancer.Semantic proximity Read ↗

Low frequency of p53 gene mutations in breast cancers of Japanese-American women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.