Article
Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.
Cancer research - 1 Apr 1993
Thorlacius S, Börresen A L, Eyfjörd J E
Abstract excerpt
Mutations in the p53 gene are among the most common genetic changes in human carcinomas. They have been found in many tumor types including colon, lung, and breast. We have used constant denaturant gel electrophoresis in order to screen samples from 109 breast carcinomas for mutations in four conserved regions, exons 5, 7, and 8, of the p53 gene. Samples were also analyzed for allelic loss of the p53 gene and of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.