Article
Somatic p53 mutations in human breast carcinomas in an Icelandic population: a prognostic factor.
Cancer research - 1 Apr 1993
Thorlacius S, Börresen A L, Eyfjörd J E
Abstract excerpt
Mutations in the p53 gene are among the most common genetic changes in human carcinomas. They have been found in many tumor types including colon, lung, and breast. We have used constant denaturant gel electrophoresis in order to screen samples from 109 breast carcinomas for mutations in four con...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Breast Neoplasms
- Chromosomes, Human, Pair 17
- Conserved Sequence
- DNA Mutational Analysis
- Exons
- Female
- Gene Deletion
- Genes, p53
- Humans
- Iceland
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction