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Article

TRF2 Mediates Replication Initiation within Human Telomeres to Prevent Telomere Dysfunction

1 Nov 2020

Abstract excerpt

The telomeric shelterin protein telomeric repeat-binding factor 2 (TRF2) recruits origin recognition complex (ORC) proteins, the foundational building blocks of DNA replication origins, to telomeres. We seek to determine whether TRF2-recruited ORC proteins give rise to functional origins in telomere repeat tracts. We find that reduction of telomeric recruitment of ORC2 by expression of an ORC...

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PMID: 33176153
DOI: 10.1016/j.celrep.2020.108379

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