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Article

The genetics and biology of Irf5-mediated signaling in lupus

1 Jan 2007

Abstract excerpt

Recently much attention was attracted to the importance of the type I interferon pathway in the initiation and development of the autoimmune disease systemic lupus erythematosus (SLE). Many SLE patients have increased serum levels of IFN-alpha and display an IFN gene expression "signature" characterized by strong overexpression of IFN-responsive genes in leukocytes and target tissues. Moreover, about 20% of...

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PMID: 18075793
DOI: 10.1080/08916930701510905

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