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Article

Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus

1 Jan 2012

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple genetic risk factors, high levels of interferon alpha (IFN-α), and the production of autoantibodies against components of the cell nucleus. Interferon regulatory factor 5 (IRF5) is a transcription factor which induces the transcription of IFN-α and other cytokines, and genetic variants of IRF5 have been strongly linked to SLE...

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Identifiers

PMID: 23251221
DOI: 10.1155/2012/780436

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