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Article

IRF5-mediated signaling and implications for SLE.

Clinical immunology (Orlando, Fla.) - 1 Aug 2014

Lazzari Elisa, Jefferies Caroline A

Abstract excerpt

Transcription of the type I IFN genes is regulated by members of the Interferon Regulatory Factor (IRF) family of transcription factors, composed in humans of 9 distinct proteins. In addition to IRF3 and IRF7, the transcription factor IRF5 has been shown to be involved in type I IFN production and interestingly, polymorphisms of the IRF5 gene in humans can result in risk or protective haplotypes with regard to...

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Identifiers

PMID: 24928322
DOI: 10.1016/j.clim.2014.06.001

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