Article
β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling.
Cardiovascular research - 1 Nov 2017
Wang Yimei, Jin Li, Song Ying, Zhang Mao, Shan Dan, Liu Yuli, Fang Meng, Lv Fengxiang, Xiao Rui-Ping, Zhang Yan
Abstract excerpt
AIMS: Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Although timely restoration of coronary blood flow (reperfusion) is the most effective therapeutics of myocardial infarction, reperfusion causes further cardiac damage, i.e. ischemia-reperfusion (I/R) injury. β-arrestins (Arrbs) have been traditionally defined as negative regulators of G protein-coupled receptor (GPCR)...
Topics
- Animals
- Caveolin 3
- Cell Death
- Cell Survival
- Class Ia Phosphatidylinositol 3-Kinase
- Disease Models, Animal
- Genetic Predisposition to Disease
- Glycogen Synthase Kinase 3 beta
- Isolated Heart Preparation
- Male