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Article

β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling.

Cardiovascular research - 1 Nov 2017

Wang Yimei, Jin Li, Song Ying, Zhang Mao, Shan Dan, Liu Yuli, Fang Meng, Lv Fengxiang, Xiao Rui-Ping, Zhang Yan

Abstract excerpt

AIMS: Ischemic heart disease is a leading cause of morbidity and mortality worldwide. Although timely restoration of coronary blood flow (reperfusion) is the most effective therapeutics of myocardial infarction, reperfusion causes further cardiac damage, i.e. ischemia-reperfusion (I/R) injury. β-arrestins (Arrbs) have been traditionally defined as negative regulators of G protein-coupled receptor (GPCR)...

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Identifiers

PMID: 29016703
DOI: 10.1093/cvr/cvx147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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