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Article

Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2006

Akhter Shahab A, D'Souza Karen M, Petrashevskaya Natalia N, Mialet-Perez Jeanne, Liggett Stephen B

Abstract excerpt

Association studies suggest beta(1)-adrenergic receptor (beta(1)-AR) polymorphisms are disease modifiers in heart failure. The Arg389 variant has increased coupling to G(s) in transfected cells and evokes enhanced ventricular function in transgenic mice. Here, we assessed the differential effects of the human Gly389 and Arg389 beta(1)-AR polymorphisms on myocardial recovery after ischemic injury. Function was...

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Source

Identifiers

PMID: 16537791
DOI: 10.1152/ajpheart.00908.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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