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Article

Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2014

Boardman N T, Aronsen J M, Louch W E, Sjaastad I, Willoch F, Christensen G, Sejersted O, Aasum E

Abstract excerpt

Sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA)2 transports Ca2+ from the cytosol into the sarcoplasmic reticulum of cardiomyocytes and is essential for maintaining myocardial Ca2+ handling and thus the mechanical function of the heart. SERCA2 is a major ATP consumer in excitation-contraction coupling but is regarded to contribute to energetically efficient Ca2+ handling in the cardiomyocyte. Previous studies...

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Source

Identifiers

PMID: 24486508
DOI: 10.1152/ajpheart.00741.2013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2.PMID 24486508Read ↗

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