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Article

Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.

Circulation research - 3 Sept 2010

Xu Xianghua, Marx Steven O, Colecraft Henry M

Abstract excerpt

RATIONALE: In heart, Ca(2+) entering myocytes via Ca(V)1.2 channels controls essential functions, including excitation-contraction coupling, action potential duration, and gene expression. RGK GTPases (Rad/Rem/Rem2/Gem/Kir sub-family of Ras-like GTPases) potently inhibit Ca(V)1.2 channels, an effect that may figure prominently in cardiac Ca(2+) homeostasis under physiological and disease conditions. OBJECTIVE: To...

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Identifiers

PMID: 20616312
DOI: 10.1161/CIRCRESAHA.110.224717
PMCID: PMC2952418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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